Novel MedTech for Hypertension and Complex Coronary Access: Dr. Fischell on Peregrine and CrossFast
MedTech Unboxed: Presented by Chamfr
What does it take to bring novel interventional devices from concept to clinical use? In this episode, Steve talks with Dr. Fischell about two innovative medtech platforms designed to address major unmet needs: the Peregrine system for renal denervation in hypertension and the CrossFast delivery system for treating highly calcified, tortuous coronary and peripheral vessels.
They discuss why hypertension remains a massive clinical problem, how the Peregrine system uses microdoses of alcohol to ablate renal sympathetic nerves, and why that approach may offer advantages over energy-based renal denervation methods. Dr. Fischell also explains the clinical challenge of delivering devices through complex anatomy and how the CrossFast platform was designed to improve access, pushability, and deliverability in difficult cases.
The conversation also covers FDA progress, commercialization, manufacturing complexity, supply chain coordination, coatings, sterilization, nitinol components, and what design and manufacturing teams should understand when building advanced catheter-based technologies. For medtech professionals working in interventional cardiology, catheter design, product development, or contract manufacturing, this is a practical look at innovation from both the clinical and commercialization side.
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